2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid
2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid
CAS: 1239963-90-6
Molecular Formula: C11H13FO3
2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid - Names and Identifiers
| Name | 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid |
| Synonyms | 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid Benzeneacetic acid, 4-fluoro-3-methoxy-α,α-dimethyl- |
| CAS | 1239963-90-6 |
2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid - Physico-chemical Properties
| Molecular Formula | C11H13FO3 |
| Molar Mass | 212.22 |
| Density | 1.185±0.06 g/cm3(Predicted) |
| Boling Point | 315.9±32.0 °C(Predicted) |
| pKa | 4.27±0.11(Predicted) |
2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid - Introduction
2-(4-fluoro-3-methoxyphenyl)-2-methylpropylaminoic acid is an organic compound with the chemical formula C11H13FO3.
Nature:
-Appearance: A white crystalline solid
-Melting point: about 74-77 degrees Celsius
-Solubility: Slightly soluble in water, soluble in most organic solvents
Use:
- 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid is widely used in the field of medicine as a drug intermediate, often used in the synthesis of anti-inflammatory, analgesic and anti-acid drugs.
Method:
2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid can be synthesized by the following steps:
1. First, 2-chloro-2-methylpropionic acid is esterified with P-fluorophenol to obtain 2-(4-fluorophenyl)-2-methylpropionic acid ester.
2. Then, hydroxylation reaction is carried out with methanol and hydrogen chloride under alkaline conditions to generate 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid.
Safety Information:
-The safety assessment of 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid is inadequate due to the absence of specific experimental reports and studies.
-Because it is an organic compound, it is necessary to comply with relevant laboratory practices and avoid direct contact with skin and eyes.
-If you come into contact with this compound, rinse immediately with plenty of water and seek medical help.
-When storing, it should be kept in a dry, cool, well-ventilated place, away from fire and oxidizing agents.
Nature:
-Appearance: A white crystalline solid
-Melting point: about 74-77 degrees Celsius
-Solubility: Slightly soluble in water, soluble in most organic solvents
Use:
- 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid is widely used in the field of medicine as a drug intermediate, often used in the synthesis of anti-inflammatory, analgesic and anti-acid drugs.
Method:
2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid can be synthesized by the following steps:
1. First, 2-chloro-2-methylpropionic acid is esterified with P-fluorophenol to obtain 2-(4-fluorophenyl)-2-methylpropionic acid ester.
2. Then, hydroxylation reaction is carried out with methanol and hydrogen chloride under alkaline conditions to generate 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid.
Safety Information:
-The safety assessment of 2-(4-fluoro-3-methoxyphenyl)-2-methylpropanoic acid is inadequate due to the absence of specific experimental reports and studies.
-Because it is an organic compound, it is necessary to comply with relevant laboratory practices and avoid direct contact with skin and eyes.
-If you come into contact with this compound, rinse immediately with plenty of water and seek medical help.
-When storing, it should be kept in a dry, cool, well-ventilated place, away from fire and oxidizing agents.
Last Update：2024-04-09 21:04:16
